Follicle-stimulating hormone, from the pituitary gland, which grows each cycle’s wave of follicles. Below are the median and the 5th to 95th percentile for each day from 15 days before the LH peak to 14 after, in mIU/mL, which is the same number in IU/L.
What is a normal FSH level in the early follicular phase?
Across days −15 to −6 before the LH peak, the pooled median FSH in Stricker and colleagues’ 20 women was 6.42 mIU/mL (6.42 IU/L). Daily medians in that window ran from 4.59 to 6.88 mIU/mL, and FSH peaked with LH, at 12.82 mIU/mL on the day of the LH peak.
Median5th to 95th percentileFSH in mIU/mL or IU/L, by day from the LH peak. Point at a day to read its figures; the table below lists every value.
FSH in each phase of the cycle
Pooled median FSH in each phase, Stricker and colleagues (2006), Table 2
Phase
Days from the LH peak
Median, mIU/mL or IU/L
Early follicular
Days −15 to −6
6.42
Late follicular
Days −5 to −1
4.66
LH peak
Day 0
12.82
Early luteal
Days +1 to +4
5.62
Mid-luteal
Days +5 to +9
3.14
Late luteal
Days +10 to +14
2.85
Each phase figure is the median of every sample taken in that phase, pooled, which is why it is not the median of the daily medians.
FSH on every day of the cycle
The second column places each day in a 28-day cycle with the LH peak on day 14, the textbook timing. Days −15 and −14 have no place in such a cycle, so it is blank for them.
Daily median, 5th and 95th percentile FSH, Stricker and colleagues (2006), Table 1
Day from the LH peak
Day of a 28-day cycle
Women
mIU/mL or IU/L
Median
5th
95th
−15
9
4.59
1.95
5.86
−14
12
6.45
2.79
8.15
−13
1
14
6.34
4.24
7.79
−12
2
17
6.26
4.62
7.93
−11
3
19
6.61
5.50
9.01
−10
4
20
6.88
5.40
10.25
−9
5
20
6.65
5.04
8.80
−8
6
20
6.46
4.97
9.53
−7
7
20
6.63
4.66
8.59
−6
8
20
5.65
4.41
8.10
−5
9
20
5.45
4.19
7.33
−4
10
20
4.59
3.83
6.33
−3
11
20
4.35
3.55
6.62
−2
12
20
4.32
2.95
5.71
−1
13
20
5.15
3.20
8.56
0
14
20
12.82
5.30
15.07
+1
15
20
8.01
5.20
15.43
+2
16
19
5.19
3.78
9.51
+3
17
20
4.73
3.05
8.18
+4
18
20
4.36
2.71
7.10
+5
19
20
3.88
2.22
5.97
+6
20
19
3.34
2.01
5.53
+7
21
20
3.31
1.47
5.34
+8
22
20
2.97
1.53
4.88
+9
23
20
2.73
1.26
4.09
+10
24
19
2.55
1.12
3.57
+11
25
20
2.54
1.09
3.26
+12
26
20
3.08
1.13
4.37
+13
27
16
3.73
1.55
7.58
+14
28
8
3.81
1.54
5.78
All 20 women were sampled on 20 of the 30 days. The ends of the table rest on fewer, 9 on day −15 and 8 on day +14, because cycles differ in length. With 20 women or fewer on a day, each percentile is set by the one or two most extreme values.
How FSH moves through the cycle
FSH falls as estradiol rises in the late follicular phase: from day −5 to day −2 the FSH median drops every day, from 5.45 to 4.32 mIU/mL, while the estradiol median climbs from 71.4 to 177.3 pg/mL.
At the surge the FSH median grows 2.97-fold from day −2 to day 0, against 5.87-fold for LH over the same two days.
Through the luteal phase the median falls to 2.54 mIU/mL on day +11, the lowest in the table, then climbs every day to 3.81 on day +14, the start of the rise that recruits the next cycle’s follicles.
Day 3 of a 28-day cycle, the day an FSH test is often booked for, is day −11 on this table if the LH peak falls on day 14. There the median was 6.61 mIU/mL and the middle 90 percent ran from 5.50 to 9.01.
The menstrual cycle hormone simulator joins these medians into curves and plays FSH against the other three hormones, with the follicle and the lining drawn day by day.
Converting between units
An international unit measures biological activity against a WHO reference preparation rather than a mass, so FSH has no molar mass to convert with, and needs none: a milli-international unit per milliliter scales the unit and the volume by the same thousand, so mIU/mL and IU/L carry the same number.
mIU/mL to IU/L
1 mIU/mL = 0.001 IU ÷ 0.001 L
= 1 IU/L
Where the numbers come from
Stricker and colleagues (2006) took blood from 20 women aged 20 to 36, with normal cycles and no hormonal contraception, on every day of one cycle, and measured FSH on an Abbott ARCHITECT analyzer in one laboratory. Each woman’s days are counted from her own LH peak, day 0, and each figure is the median of the women sampled that day.
The tables were read from the authors’ own copy of the paper, and every figure was checked against the independent transcription behind Häggström’s reference range charts.
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