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Great cardiac vein

The great cardiac vein is one of the veins that drain the heart. It begins at the apex, climbs the anterior interventricular sulcus, then turns left in the coronary sulcus to the left end of the coronary sinus at the back of the heart. (OpenStax A&P 2e, 19.1; Gray 1918, 3. The Systemic Veins; StatPearls, Heart Veins)

Latin vena cordis magna, vena cardiaca magna (Wikipedia, Great cardiac vein, CC BY-SA 4.0) · FMA4707 · Cardiovascular system

Front view of the heart model with the wall faded and the great cardiac vein highlighted, climbing the front of the heart beside the anterior interventricular artery.
The great cardiac vein, highlighted in the heart model seen from the front with the wall faded. Render: ScienceQuest, CC BY 4.0. Meshes: BodyParts3D, © The Database Center for Life Science, CC BY 4.0
The great cardiac vein on its own, seen from the front.
The great cardiac vein alone, from the front. Render: ScienceQuest, CC BY 4.0. Meshes: BodyParts3D, © The Database Center for Life Science, CC BY 4.0

Open it in the Heart Explorer See it alone in 3D

Where does the great cardiac vein run?

It starts at the apex and climbs the anterior interventricular sulcus beside the anterior interventricular artery, toward the base of the left auricle. (StatPearls, Heart Veins)

At the left margin of the heart it turns onto the back. There it meets the oblique vein of the left atrium, and the two form the coronary sinus. (StatPearls, Heart Veins and Coronary Sinus)

The valve of Vieussens sits at its end, where the coronary sinus begins. (StatPearls, Coronary Sinus)

What does the great cardiac vein drain?

It drains the area that the anterior interventricular artery supplies, carrying blood from both ventricles and the left atrium toward the right atrium. (OpenStax A&P 2e, 19.1; StatPearls, Heart Veins)

It belongs to the greater cardiac venous system, which drains most of the blood from the heart muscle, and it is one of the tributaries of the coronary sinus. (StatPearls, Heart Veins)

Which veins lie near the great cardiac vein?

The oblique vein of the left atrium, which it meets at the start of the coronary sinus, has no valve at its junction with the sinus, where the other tributaries have one. (StatPearls, Coronary Sinus)

Does the great cardiac vein vary?

It and the coronary sinus show the most notable variations among the cardiac veins. It runs along the anterior interventricular sulcus as a rule, but in some people it runs inside the heart wall, which can hinder its flow. (StatPearls, Heart Veins)

Where the sources differ

The sources disagree on where the middle and small cardiac veins end. OpenStax lists them, with the posterior cardiac vein, as branches the great cardiac vein receives; the StatPearls articles have them draining into the coronary sinus itself. (OpenStax A&P 2e, 19.1; StatPearls, Coronary Sinus and Heart Veins)

Great cardiac vein: course and drainage
Feature Detail and source
Begins At the apex of the heart (StatPearls, Heart Veins)
Runs in The anterior interventricular sulcus, then the coronary sulcus (OpenStax A&P 2e, 19.1; Gray 1918, 3. The Systemic Veins; StatPearls, Heart Veins)
Ends Joins the oblique vein of the left atrium to form the coronary sinus (StatPearls, Coronary Sinus)
Accompanies Anterior interventricular artery (OpenStax A&P 2e, 19.1; StatPearls, Heart Veins)

Touches in this model

Measured on the BodyParts3D meshes: surfaces within 2 mm of the great cardiac vein, nearest first.

Sources

  1. OpenStax Anatomy and Physiology 2e, section 19.1, Heart Anatomy. CC BY-NC-SA 4.0. Read 2026-10-25.
  2. Gray’s Anatomy of the Human Body, 20th US edition (1918), VII. The Veins, 3. The Systemic Veins (1918 terms: longitudinal sulcus for interventricular sulcus). Henry Gray. Public domain. Read 2026-10-25.
  3. StatPearls, Anatomy, Thorax, Heart Veins. Julia H. Miao; Amgad N. Makaryus. Last update July 24, 2023. CC BY-NC-ND 4.0. Read 2026-10-25.
  4. StatPearls, Anatomy, Thorax, Coronary Sinus. Alexander Wilson; Beenish S. Bhutta. Last update July 24, 2023. CC BY-NC-ND 4.0. Read 2026-10-25.

The values are facts and free to use; this page’s selection and presentation are © 2026 ScienceQuest.